Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains

Bromodomains have been pursued intensively over the past several years as emerging targets for the development of anti-cancer and anti-inflammatory agents. It has recently been shown that some kinase inhibitors are able to potently inhibit the bromodomains of BRD4. The clinical activities of PLK inh...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Wang, Jinhua, Erazo, Tatiana, Ferguson, Fleur M., Buckley, Dennis L., Gomez, Nestor, Muñoz-Guardiola, Pau, Diéguez-Martínez, Nora, Deng, Xianming, Hao, Mingfeng, Massefski, Walter, Fedorov, Oleg, Offei-Addo, Nana Kwaku, Park, Paul M., Dai, Lingling, DiBona, Amy, Becht, Kelly, Kim, Nam Doo, McKeown, Michael R., Roberts, Justin M., Zhang, Jinwei, Sim, Taebo, Alessi, Dario R., Bradner, James E., Lizcano, Jose M., Blacklow, Stephen C., Qi, Jun, Xu, Xiang, Gray, Nathanael S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333101/
https://ncbi.nlm.nih.gov/pubmed/30102854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00638
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