Structure-activity relationships of Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human Insulin-Degrading Enzyme

Insulin degrading enzyme (IDE) is a zinc metalloprotease that degrades small amyloid peptides such as amyloid-β and insulin. So far the dearth of IDE-specific pharmacological inhibitors impacts the understanding of its role in the physiopathology of Alzheimer’s disease, amyloid-β clearance, and its...

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Publicado en:Eur J Med Chem
Autores principales: Charton, Julie, Gauriot, Marion, Totobenazara, Jane, Hennuyer, Nathalie, Dumont, Julie, Bosc, Damien, Marechal, Xavier, Elbakali, Jamal, Herledan, Adrien, Wen, Xiaoan, Ronco, Cyril, Gras-Masse, Helene, Heninot, Antoine, Pottiez, Virginie, Landry, Valerie, Staels, Bart, Liang, Wenguang G., Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325277/
https://ncbi.nlm.nih.gov/pubmed/25489670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.12.005
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