Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

Substrates of Insulin-Degrading Enzyme are numerous and share little homology, like amyloid-beta and insulin. Small molecules binding both at the permanent exosite and at the discontinuous, conformational catalytic site, were discovered and co-crystallized with Insulin-Degrading Enzyme. Selective in...

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Detalhes bibliográficos
Main Authors: Charton, Julie, Gauriot, Marion, Guo, Qing, Hennuyer, Nathalie, Marechal, Xavier, Dumont, Julie, Hamdane, Malika, Pottiez, Virginie, Landry, Valerie, Sperandio, Olivier, Flipo, Marion, Buee, Luc, Staels, Bart, Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128174/
https://ncbi.nlm.nih.gov/pubmed/24735644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.04.009
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