Structure-based molecular modeling in SAR analysis and lead optimization

door Temml, Veronika, Kutil, Zsofia
Gepubliceerd in Comput Struct Biotechnol J (2021)

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2

door Kaserer, Teresa, Temml, Veronika, Kutil, Zsofia, Vanek, Tomas, Landa, Premysl, Schuster, Daniela
Gepubliceerd in Eur J Med Chem (2015)

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity

door Kutil, Zsofia, Temml, Veronika, Maghradze, David, Pribylova, Marie, Dvorakova, Marcela, Schuster, Daniela, Vanek, Tomas, Landa, Premysl
Gepubliceerd in 2014

Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models

door Tavares, Maurício T., Shen, Sida, Knox, Tessa, Hadley, Melissa, Kutil, Zsófia, Bařinka, Cyril, Villagra, Alejandro, Kozikowski, Alan P.
Gepubliceerd in ACS Med Chem Lett (2017)

Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors

door Kutil, Zsófia, Mikešová, Jana, Zessin, Matthes, Meleshin, Marat, Nováková, Zora, Alquicer, Glenda, Kozikowski, Alan, Sippl, Wolfgang, Bařinka, Cyril, Schutkowski, Mike
Gepubliceerd in ACS Omega (2019)

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

door Temml, Veronika, Garscha, Ulrike, Romp, Erik, Schubert, Gregor, Gerstmeier, Jana, Kutil, Zsofia, Matuszczak, Barbara, Waltenberger, Birgit, Stuppner, Hermann, Werz, Oliver, Schuster, Daniela
Gepubliceerd in Sci Rep (2017)

The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

door Ustinova, Kseniya, Novakova, Zora, Saito, Makoto, Meleshin, Marat, Mikesova, Jana, Kutil, Zsofia, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Matthias, Patrick, Barinka, Cyril
Gepubliceerd in J Biol Chem (2020)

Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules

door Skultetyova, Lubica, Ustinova, Kseniya, Kutil, Zsofia, Novakova, Zora, Pavlicek, Jiri, Mikesova, Jana, Trapl, Dalibor, Baranova, Petra, Havlinova, Barbora, Hubalek, Martin, Lansky, Zdenek, Barinka, Cyril
Gepubliceerd in Sci Rep (2017)

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

door Kozikowski, Alan P., Shen, Sida, Pardo, Marta, Tavares, Maurício T., Szarics, Dora, Benoy, Veronick, Zimprich, Chad A., Kutil, Zsófia, Zhang, Guiping, Bařinka, Cyril, Robers, Matthew B., Van Den Bosch, Ludo, Eubanks, James H., Jope, Richard S.
Gepubliceerd in ACS Chem Neurosci (2018)