The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

Histone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase activity that has been unequivocally assigned to the second of the tandem catalytic domains. However, virtually no information exists on the contribution of other HDAC6 domains on tubulin recognition. Here, us...

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Опубликовано в: :J Biol Chem
Главные авторы: Ustinova, Kseniya, Novakova, Zora, Saito, Makoto, Meleshin, Marat, Mikesova, Jana, Kutil, Zsofia, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Matthias, Patrick, Barinka, Cyril
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Enzymology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049964/
https://ncbi.nlm.nih.gov/pubmed/31953325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011243
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