The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

Histone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase activity that has been unequivocally assigned to the second of the tandem catalytic domains. However, virtually no information exists on the contribution of other HDAC6 domains on tubulin recognition. Here, us...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Ustinova, Kseniya, Novakova, Zora, Saito, Makoto, Meleshin, Marat, Mikesova, Jana, Kutil, Zsofia, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Matthias, Patrick, Barinka, Cyril
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049964/
https://ncbi.nlm.nih.gov/pubmed/31953325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011243
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