The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

Histone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase activity that has been unequivocally assigned to the second of the tandem catalytic domains. However, virtually no information exists on the contribution of other HDAC6 domains on tubulin recognition. Here, us...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Ustinova, Kseniya, Novakova, Zora, Saito, Makoto, Meleshin, Marat, Mikesova, Jana, Kutil, Zsofia, Baranova, Petra, Havlinova, Barbora, Schutkowski, Mike, Matthias, Patrick, Barinka, Cyril
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049964/
https://ncbi.nlm.nih.gov/pubmed/31953325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011243
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