Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules

Human histone deacetylase 6 (HDAC6) is the major deacetylase responsible for removing the acetyl group from Lys40 of α-tubulin (αK40), which is located lumenally in polymerized microtubules. Here, we provide a detailed kinetic analysis of tubulin deacetylation and HDAC6/microtubule interactions usin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Skultetyova, Lubica, Ustinova, Kseniya, Kutil, Zsofia, Novakova, Zora, Pavlicek, Jiri, Mikesova, Jana, Trapl, Dalibor, Baranova, Petra, Havlinova, Barbora, Hubalek, Martin, Lansky, Zdenek, Barinka, Cyril
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599508/
https://ncbi.nlm.nih.gov/pubmed/28912522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11739-3
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