Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models

[Image: see text] Only a handful of therapies offer significant improvement in the overall survival in cases of melanoma, a cancer whose incidence has continued to rise in the past 30 years. In our effort to identify potent and isoform-selective histone deacetylase (HDAC) inhibitors as a therapeutic...

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Udgivet i:ACS Med Chem Lett
Main Authors: Tavares, Maurício T., Shen, Sida, Knox, Tessa, Hadley, Melissa, Kutil, Zsófia, Bařinka, Cyril, Villagra, Alejandro, Kozikowski, Alan P.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641951/
https://ncbi.nlm.nih.gov/pubmed/29057046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00223
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