Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and ADMET properties, and its ability to impro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Kozikowski, Alan P., Shen, Sida, Pardo, Marta, Tavares, Maurício T., Szarics, Dora, Benoy, Veronick, Zimprich, Chad A., Kutil, Zsófia, Zhang, Guiping, Bařinka, Cyril, Robers, Matthew B., Van Den Bosch, Ludo, Eubanks, James H., Jope, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512341/
https://ncbi.nlm.nih.gov/pubmed/30511829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00600
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados