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Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
Human histone deacetylase 6 (HDAC6) is the major deacetylase responsible for removing the acetyl group from Lys40 of α-tubulin (αK40), which is located lumenally in polymerized microtubules. Here, we provide a detailed kinetic analysis of tubulin deacetylation and HDAC6/microtubule interactions usin...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5599508/ https://ncbi.nlm.nih.gov/pubmed/28912522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11739-3 |
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