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Structural characterization of P1′-diversified urea-based inhibitors of glutamate carboxypeptidase II
Urea-based inhibitors of human glutamate carboxypeptidase II (GCPII) have advanced into clinical trials for imaging metastatic prostate cancer. In parallel efforts, agents with increased lipophilicity have been designed and evaluated for targeting GCPII residing within the neuraxis. Here we report t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077459/ https://ncbi.nlm.nih.gov/pubmed/24731280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.03.066 |
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