Structural characterization of P1′-diversified urea-based inhibitors of glutamate carboxypeptidase II

Urea-based inhibitors of human glutamate carboxypeptidase II (GCPII) have advanced into clinical trials for imaging metastatic prostate cancer. In parallel efforts, agents with increased lipophilicity have been designed and evaluated for targeting GCPII residing within the neuraxis. Here we report t...

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Bibliografiset tiedot
Päätekijät: Pavlicek, Jiri, Ptacek, Jakub, Cerny, Jiri, Byun, Youngjoo, Skultetyova, Lubica, Pomper, Martin G., Lubkowski, Jacek, Barinka, Cyril
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077459/
https://ncbi.nlm.nih.gov/pubmed/24731280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.03.066
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