Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity

Virtually all low molecular weight inhibitors of human glutamate carboxypeptidase II (GCPII) are highly polar compounds that have limited use in settings where more lipophilic molecules are desired. Here we report the identification and characterization of GCPII inhibitors with enhanced liphophilici...

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Detalhes bibliográficos
Main Authors: Plechanovová, Anna, Byun, Youngjoo, Alquicer, Glenda, Škultétyová, Ľubica, Mlčochová, Petra, Němcová, Adriana, Kim, Hyung-Joon, Navrátil, Michal, Mease, Ronnie, Lubkowski, Jacek, Pomper, Martin, Konvalinka, Jan, Rulíšek, Lubomír, Bařinka, Cyril
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222833/
https://ncbi.nlm.nih.gov/pubmed/21923190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200807m
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