Reaction Mechanism of Glutamate Carboxypeptidase II Revealed by Mutagenesis, X-ray Crystallography, and Computational Methods

Glutamate carboxypeptidase II (GCPII, EC 3.4.17.21) is a zinc-dependent exopeptidase and an important therapeutic target for neurodegeneration and prostate cancer. The hydrolysis of N-acetyl-l-aspartyl-l-glutamate (N-Ac-Asp-Glu), the natural dipeptidic substrate of the GCPII, is intimately involved...

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Bibliografiska uppgifter
I publikationen:Biochemistry
Huvudupphovsmän: Klusák, Vojtêch, Bařinka, Cyril, Plechanovová, Anna, Mlčochová, Petra, Konvalinka, Jan, Rulíšek, Lubomír, Lubkowski, Jacek
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289149/
https://ncbi.nlm.nih.gov/pubmed/19301871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900220s
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