Structural Basis of Interactions between Human Glutamate Carboxypeptidase II and Its Substrate Analogs

Human glutamate carboxypeptidase II (GCPII) is involved in neuronal signal transduction and intestinal folate absorption by means of the hydrolysis of its two natural substrates, N-acetyl-aspartyl-glutamate (NAAG) and folyl-poly-γ-glutamates, respectively. During the past years, tremendous efforts h...

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Main Authors: Barinka, Cyril, Hlouchova, Klara, Rovenska, Miroslava, Majer, Pavel, Dauter, Miroslawa, Hin, Niyada, Ko, Yao-Sen, Tsukamoto, Takashi, Slusher, Barbara S., Konvalinka, Jan, Lubkowski, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753231/
https://ncbi.nlm.nih.gov/pubmed/18234225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.066
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