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Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
Membrane-bound glutamate carboxypeptidase II (GCPII) is a zinc metalloenzyme that catalyzes the hydrolysis of the neurotransmitter N-acetyl-L-aspartyl-L-glutamate (NAAG) to N-acetyl-L-aspartate and L-glutamate (which is itself a neurotransmitter). Potent and selective GCPII inhibitors have been show...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1422165/ https://ncbi.nlm.nih.gov/pubmed/16467855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600969 |
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