Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization()

Urea-based, low molecular weight ligands of glutamate carboxypeptidase II (GCPII) have demonstrated efficacy in various models of neurological disorders and can serve as imaging agents for prostate cancer. To enhance further development of such compounds, we determined X-ray structures of four compl...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Barinka, Cyril, Byun, Youngjoo, Dusich, Crystal L., Banerjee, Sangeeta R., Chen, Ying, Castanares, Mark, Kozikowski, Alan P., Mease, Ronnie C., Pomper, Martin G., Lubkowski, Jacek
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516903/
https://ncbi.nlm.nih.gov/pubmed/19053759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800765e
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