Interactions between Human Glutamate Carboxypeptidase II and Urea-Based Inhibitors: Structural Characterization()

Urea-based, low molecular weight ligands of glutamate carboxypeptidase II (GCPII) have demonstrated efficacy in various models of neurological disorders and can serve as imaging agents for prostate cancer. To enhance further development of such compounds, we determined X-ray structures of four compl...

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Publicado en:J Med Chem
Autores principales: Barinka, Cyril, Byun, Youngjoo, Dusich, Crystal L., Banerjee, Sangeeta R., Chen, Ying, Castanares, Mark, Kozikowski, Alan P., Mease, Ronnie C., Pomper, Martin G., Lubkowski, Jacek
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516903/
https://ncbi.nlm.nih.gov/pubmed/19053759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800765e
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