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Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities
Inhibitors targeting human glutamate carboxypeptidase II (GCPII) typically consist of a P1’ glutamate-derived binding module, which warrants the high-affinity and specificity, linked to an effector function that is positioned within the entrance funnel of the enzyme. Here we present a comprehensive...
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| Publicado no: | FEBS J |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712110/ https://ncbi.nlm.nih.gov/pubmed/26460595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13557 |
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