Bioisosterism of Urea-Based GCPII Inhibitors: Synthesis and Structure-Activity Relationships Studies

We report a strategy based on bioisosterism to improve the physicochemical properties of existing hydrophilic, urea-based GCPII inhibitors. Comprehensive structure-activity relationship studies of the P1’ site of ZJ-43- and DCIBzL-based compounds identified several glutamate-free inhibitors with K(i...

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Detalhes bibliográficos
Main Authors: Wang, Haofan, Byun, Youngjoo, Barinka, Cyril, Pullambhatla, Mrudula, Bhang, Hyoeun C., Fox, James J., Lubkowski, Jacek, Mease, Ronnie C., Pomper, Martin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818328/
https://ncbi.nlm.nih.gov/pubmed/19897367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.061
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