Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II

Glutamate carboxypeptidase II (GCPII) is an important target for therapeutic and diagnostic interventions aimed at prostate cancer and neurologic disorders. Here we describe the development and optimization of a high-throughput screening (HTS) assay based on fluorescence polarization (FP) that facil...

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Main Authors: Alquicer, Glenda, Sedlák, David, Byun, Youngjoo, Pavlíček, Jiří, Stathis, Marigo, Rojas, Camilo, Slusher, Barbara, Pomper, Martin G., Bartůněk, Petr, Bařinka, Cyril
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112551/
https://ncbi.nlm.nih.gov/pubmed/22751730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112451924
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