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Structure-based molecular modeling in SAR analysis and lead optimization

In silico methods like molecular docking and pharmacophore modeling are established strategies in lead identification. Their successful application for finding new active molecules for a target is reported by a plethora of studies. However, once a potential lead is identified, lead optimization, wit...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Temml, Veronika, Kutil, Zsofia
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979990/
https://ncbi.nlm.nih.gov/pubmed/33777339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.02.018
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