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LeadOp+R: Structure-Based Lead Optimization With Synthetic Accessibility
We previously described a structure-based fragment hopping for lead optimization using a pre-docked fragment database, “LeadOp,” that conceptually replaced “bad” fragments of a ligand with “good” fragments while leaving the core of the ligand intact thus improving the compound's activity. LeadO...
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| Publicado no: | Front Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5845126/ https://ncbi.nlm.nih.gov/pubmed/29556192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00096 |
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