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Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability

Secondary alkylcarbamic acid biphenyl-3-yl esters are a class of Fatty Acid Amide Hydrolase (FAAH) inhibitors, which include the reference compounds URB597 and URB694. Given the intrinsic reactivity of the carbamate group, the in vivo potency of these molecules in rats is strongly affected by their...

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書誌詳細
主要な著者: Vacondio, Federica, Silva, Claudia, Lodola, Alessio, Carmi, Caterina, Rivara, Silvia, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Clapper, Jason R., Piomelli, Daniele, Tarzia, Giorgio, Mor, Marco
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714604/
https://ncbi.nlm.nih.gov/pubmed/21820769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.07.021
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