Structure-property relationships of a class of carbamate-based Fatty Acid Amide Hydrolase (FAAH) inhibitors: chemical and biological stability

Cyclohexylcarbamic acid aryl esters are a class of Fatty Acid Amide Hydrolase (FAAH) inhibitors, which includes the reference compound URB597. The reactivity of their carbamate fragment is involved in pharmacological activity and may affect pharmacokinetic and toxicological properties. We conducted...

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Autores principales: Vacondio, Federica, Silva, Claudia, Lodola, Alessio, Fioni, Alessandro, Rivara, Silvia, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Clapper, Jason, Piomelli, Daniele, Mor, Marco, Tarzia, Giorgio
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517974/
https://ncbi.nlm.nih.gov/pubmed/19554599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900120
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