Optimization of Substituted Imidazobenzodiazepines as Novel Asthma Treatments

We describe the synthesis of analogs of XHE-III-74, a selective α4β3γ2 GABA(A)R ligand, shown to relax airway smooth muscle ex vivo and reduce airway hyperresponsiveness in a murine asthma model. To improve properties of this compound as an asthma therapeutic, a series of analogs with a deuterated m...

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發表在:Eur J Med Chem
Main Authors: Jahan, Rajwana, Stephen, Michael Rajesh, Forkuo, Gloria S., Kodali, Revathi, Guthrie, Margaret L., Nieman, Amanda N., Yuan, Nina Y., Zahn, Nicolas M., Poe, Michael M., Li, Guanguan, Yu, Olivia B., Yocum, Gene T., Emala, Charles W., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253108/
https://ncbi.nlm.nih.gov/pubmed/27915170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.11.045
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