Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABA(A) Receptor Modulators

We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α(4)β(3)γ(2) GABA(A)R selective compound 1 and acidic α(5)β(3)γ(2) selective GABA(A)R positive allosteric modulator compound 2 relaxed airway smooth muscle ex vivo and attenuated airway...

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Bibliografske podrobnosti
izdano v:Mol Pharm
Main Authors: Forkuo, Gloria S., Nieman, Amanda N., Yuan, Nina Y., Kodali, Revathi, Yu, Olivia B., Zahn, Nicolas M., Jahan, Rajwana, Li, Guanguan, Stephen, Michael Rajesh, Guthrie, Margaret L., Poe, Michael M., Hartzler, Benjamin D., Harris, Ted W., Yocum, Gene T., Emala, Charles W., Steeber, Douglas A., Stafford, Douglas C., Cook, James M., Arnold, Leggy A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497587/
https://ncbi.nlm.nih.gov/pubmed/28440659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00183
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