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A novel GABA(A) receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo
Airway smooth muscle (ASM) cells express GABA A receptors (GABA(A)Rs), and previous reports have demonstrated that GABA(A)R activators relax ASM. However, given the activity of GABA(A)Rs in central nervous system inhibitory neurotransmission, concern exists that these activators may lead to undesira...
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| Publicat a: | Am J Physiol Lung Cell Mol Physiol |
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| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6397346/ https://ncbi.nlm.nih.gov/pubmed/30489155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00356.2018 |
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