Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone

TMEM16A (anoctamin 1) is an important calcium-activated chloride channel in airway smooth muscle (ASM). We have previously shown that TMEM16A antagonists such as benzbromarone relax ASM and have proposed TMEM16A antagonists as novel therapies for asthma treatment. However, TMEM16A is also expressed...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Danielsson, Jennifer, Kuforiji, Aisha S., Yocum, Gene T., Zhang, Yi, Xu, Dingbang, Gallos, George, Emala, Charles W.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052675/
https://ncbi.nlm.nih.gov/pubmed/31747299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00552.2018
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