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Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone
TMEM16A (anoctamin 1) is an important calcium-activated chloride channel in airway smooth muscle (ASM). We have previously shown that TMEM16A antagonists such as benzbromarone relax ASM and have proposed TMEM16A antagonists as novel therapies for asthma treatment. However, TMEM16A is also expressed...
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| Publicado no: | Am J Physiol Lung Cell Mol Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7052675/ https://ncbi.nlm.nih.gov/pubmed/31747299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00552.2018 |
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