Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models

[Image: see text] We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric γ-aminobutyric acid type A receptor (GABA(A)R) modulator. The therapeutic efficacy of nebulized MIDD0301 in reducing airway resistance was investigated in spontaneous breathi...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Zahn, Nicolas M., Mikulsky, Brandon N., Roni, M. S. Rashid, Yocum, Gene T., Mian, Md Yeunus, Knutson, Daniel E., Cook, James M., Emala, Charles W., Stafford, Douglas C., Arnold, Leggy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737320/
https://ncbi.nlm.nih.gov/pubmed/33344908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00180
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