Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models

[Image: see text] We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric γ-aminobutyric acid type A receptor (GABA(A)R) modulator. The therapeutic efficacy of nebulized MIDD0301 in reducing airway resistance was investigated in spontaneous breathi...

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Bibliografiska uppgifter
I publikationen:ACS Pharmacol Transl Sci
Huvudupphovsmän: Zahn, Nicolas M., Mikulsky, Brandon N., Roni, M. S. Rashid, Yocum, Gene T., Mian, Md Yeunus, Knutson, Daniel E., Cook, James M., Emala, Charles W., Stafford, Douglas C., Arnold, Leggy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2020
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737320/
https://ncbi.nlm.nih.gov/pubmed/33344908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00180
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