A novel GABA(A) receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo

Airway smooth muscle (ASM) cells express GABA A receptors (GABA(A)Rs), and previous reports have demonstrated that GABA(A)R activators relax ASM. However, given the activity of GABA(A)Rs in central nervous system inhibitory neurotransmission, concern exists that these activators may lead to undesira...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Yocum, Gene T., Perez-Zoghbi, Jose F., Danielsson, Jennifer, Kuforiji, Aisha S., Zhang, Yi, Li, Guanguan, Rashid Roni, M. S., Kodali, Revathi, Stafford, Douglas C., Arnold, Leggy A., Cook, James M., Emala, Charles W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397346/
https://ncbi.nlm.nih.gov/pubmed/30489155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00356.2018
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