Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

著者: Agharbaoui, Fatima E., Hoyte, Ashley C., Ferro, Stefania, Gitto, Rosaria, Buemi, Maria Rosa, Fuchs, James R., Kvaratskhelia, Mamuka, De Luca, Laura
出版年 Eur J Med Chem (2016)

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

著者: Hoyte, Ashley C., Jamin, Augusta V., Koneru, Pratibha C., Kobe, Matthew J., Larue, Ross C., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka
出版年 J Biol Chem (2017)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

著者: Koneru, Pratibha C, Francis, Ashwanth C, Deng, Nanjie, Rebensburg, Stephanie V, Hoyte, Ashley C, Lindenberger, Jared, Adu-Ampratwum, Daniel, Larue, Ross C, Wempe, Michael F, Engelman, Alan N, Lyumkis, Dmitry, Fuchs, James R, Levy, Ronald M, Melikyan, Gregory B, Kvaratskhelia, Mamuka
出版年 eLife (2019)