Development of sigma-1 (σ(1)) receptor fluorescent ligands as versatile tools to study σ(1) receptors(✩)

Por Abate, Carmen, Riganti, Chiara, Pati, Maria Laura, Ghigo, Dario, Berardi, Francesco, Mavlyutov, Timur, Guo, Lian-Wang, Ruoho, Arnold
Publicado no Eur J Med Chem (2015)

Symmetrical bis-tertiary amines as novel CXCR4 inhibitors

Por Bai, Renren, Liang, Zhongxing, Yoon, Younghyoun, Liu, Shuangping, Gaines, Theresa, Oum, Yoonhyeun, Shi, Qi, Mooring, Suazette Reid, Shim, Hyunsuk
Publicado no Eur J Med Chem (2016)

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives

Por Ahmed, Nermin S., Ali, Amal H., El-Nashar, Shreen M., Gary, Bernard D., Fajardo, Alexandra M., Tinsley, Heather N., Piazza, Gary A., Negri, Matthias, Abadi, Ashraf H.
Publicado no Eur J Med Chem (2012)

Discovery and development of natural product oridonin-inspired anticancer agents

Por Ding, Ye, Ding, Chunyong, Ye, Na, Liu, Zhiqing, Wold, Eric A., Chen, Haiying, Wild, Christopher, Shen, Qiang, Zhou, Jia
Publicado no Eur J Med Chem (2016)

Targeting telomerase with radiolabeled inhibitors

Por Waghorn, Philip A., Jackson, Mark R., Gouverneur, Veronique, Vallis, Katherine A.
Publicado no Eur J Med Chem (2017)

Oligonucleotide transition state analogues of saporin L3

Por Mason, Jennifer M., Yuan, Hongling, Evans, Gary B., Tyler, Peter C., Du, Quan, Schramm, Vern L.
Publicado no Eur J Med Chem (2016)

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

Por Farahat, Abdelbasset A., Kumar, Arvind, Say, Martial, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Wilson, W. David, Boykin, David W.
Publicado no Eur J Med Chem (2017)

Synthesis, Optimization and Structure-Activity Relationships of 3,5-Disubstituted Isoxazolines as New Anti-tuberculosis Agents

Por Rakesh, Dianqing Sun, Lee, Robin B., Tangallapally, Rajendra, Lee, Richard E.
Publicado em 2008

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Por Deng, Bo-Liang, Zhao, Yujie, Hartman, Tracy L., Watson, Karen, Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
Publicado em 2008

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes

Por Bertini, Simone, De Cupertinis, Andrea, Granchi, Carlotta, Bargagli, Barbara, Tuccinardi, Tiziano, Martinelli, Adriano, Macchia, Marco, Gunther, Jillian R., Carlson, Kathryn E., Katzenellenbogen, John A., Minutolo, Filippo
Publicado em 2011

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides

Por Raffa, Demetrio, Maggio, Benedetta, Plescia, Fabiana, Cascioferro, Stella, Plescia, Salvatore, Raimondi, Maria Valeria, Daidone, Giuseppe, Tolomeo, Manlio, Grimaudo, Stefania, Di Cristina, Antonietta, Pipitone, Rosaria Maria, Bai, Ruoli, Hamel, Ernest
Publicado em 2011

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin

Por Varbanov, Hristo, Valiahdi, Seied M., Legin, Anton A., Jakupec, Michael A., Roller, Alexander, Galanski, Mathea S., Keppler, Bernhard K.
Publicado em 2011

Analogs of Pentamidine as Potential Anti-Pneumocystis Chemotherapeutics

Por Maciejewska, Dorota, Żabinski, Jerzy, Kaźmierczak, Pawel, Rezler, Mateusz, Krassowska-Świebocka, Barbara, Collins, Margaret S., Cushion, Melanie T.
Publicado em 2011

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

Por Perjési, Pal, Das, Umashankar, De Clercq, Erik, Balzarini, Jan, Kawase, Masame, Sakagami, Hiroshi, Stables, James P., Lorand, Tamas, Rozmer, Zsuzsanna, Dimmock, Jonathan R.
Publicado em 2007

Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-L-Cysteine Derivatives

Por Nichols, Daniel B., Fournet, Guy, Gurukumar, K. R., Basu, Amartya, Lee, Jin-Ching, Sakamoto, Naoya, Kozielski, Frank, Musmuca, Ira, Joseph, Benoît, Ragno, Rino, Kaushik-Basu, Neerja
Publicado em 2012

Synthesis and Biological Evaluation in U87MG Glioma Cells of (Ethynylthiophene)Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors

Por Nuti, Elisa, Casalini, Francesca, Santamaria, Salvatore, Gabelloni, Pamela, Bendinelli, Sara, Da Pozzo, Eleonora, Costa, Barbara, Marinelli, Luciana, La Pietra, Valeria, Novellino, Ettore, Bernardo, M. Margarida, Fridman, Rafael, Da Settimo, Federico, Martini, Claudia, Rossello, Armando
Publicado em 2011

The synthesis of 2,5-Bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

Por Opsenica, Igor, Filipovic, Vuk, Nuss, Jon E., Gomba, Laura M., Opsenica, Dejan, Burnett, James C., Gussio, Rick, Solaja, Bogdan A., Bavari, Sina
Publicado em 2012

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

Por Banerjee, Moloy, Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Munde, Manoj M., Wilson, W. David, Zhu, Xiaohua, Werbovetz, Karl A., Boykin, David W.
Publicado em 2012

Synthesis of Quinoline Derivatives: Discovery of a Potent and Selective Phosphodiesterase 5 Inhibitor for the Treatment of Alzheimer's disease

Por Fiorito, Jole, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Feng, Yan, Francis, Yitshak I., Rao, Sudha, Thakkar, Devarshi M., Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio
Publicado em 2012

UNC1062, a new and potent Mer inhibitor

Por Liu, Jing, Zhang, Weihe, Stashko, Michael A, DeRyckere, Deborah, Cummings, Christopher T., Hunter, Debra, Yang, Chao, Jayakody, Chatura N., Cheng, Nancy, Simpson, Catherine, Norris-Drouin, Jacqueline, Sather, Susan, Kireev, Dmitri, Janzen, William P., Earp, H Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2013