Synthesis of Quinoline Derivatives: Discovery of a Potent and Selective Phosphodiesterase 5 Inhibitor for the Treatment of Alzheimer's disease

Phosphodiesterase type 5 (PDE5) mediates the degradation of cGMP in a variety of tissues including brain. Recent studies have demonstrated the importance of the nitric oxide/cGMP/cAMP-responsive element-binding protein (CREB) pathway to the process of learning and memory. Thus, PDE5 inhibitors (PDE5...

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Detalhes bibliográficos
Main Authors: Fiorito, Jole, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Feng, Yan, Francis, Yitshak I., Rao, Sudha, Thakkar, Devarshi M., Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582828/
https://ncbi.nlm.nih.gov/pubmed/23313637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.12.009
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