Preparation of Oligomeric β-amyloid(1-42) and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Impairment of synaptic connections is likely to underlie the subtle amnesic changes occurring at the early stages of Alzheimer s Disease (AD). β-amyloid (Aβ), a peptide produced in high amounts in AD, is known to reduce Long-Term Potentiation (LTP), a cellular correlate of learning and memory. Indee...

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Bibliographic Details
Main Authors: Fa, Mauro, Orozco, Ian J., Francis, Yitshak I., Saeed, Faisal, Gong, Yimin, Arancio, Ottavio
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2010
Subjects:
JoVE Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156071/
https://ncbi.nlm.nih.gov/pubmed/20644518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/1884
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