Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here, we examined the time course of synaptic changes in mouse hippocampal neurons following exposure to Aβ(42) at picomolar concentrations, mimic...

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Foilsithe in:Sci Rep
Main Authors: Koppensteiner, Peter, Trinchese, Fabrizio, Fà, Mauro, Puzzo, Daniela, Gulisano, Walter, Yan, Shijun, Poussin, Arthur, Liu, Shumin, Orozco, Ian, Dale, Elena, Teich, Andrew F., Palmeri, Agostino, Ninan, Ipe, Boehm, Stefan, Arancio, Ottavio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007504/
https://ncbi.nlm.nih.gov/pubmed/27581852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32553
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