Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here, we examined the time course of synaptic changes in mouse hippocampal neurons following exposure to Aβ(42) at picomolar concentrations, mimic...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Koppensteiner, Peter, Trinchese, Fabrizio, Fà, Mauro, Puzzo, Daniela, Gulisano, Walter, Yan, Shijun, Poussin, Arthur, Liu, Shumin, Orozco, Ian, Dale, Elena, Teich, Andrew F., Palmeri, Agostino, Ninan, Ipe, Boehm, Stefan, Arancio, Ottavio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007504/
https://ncbi.nlm.nih.gov/pubmed/27581852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32553
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