Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here, we examined the time course of synaptic changes in mouse hippocampal neurons following exposure to Aβ(42) at picomolar concentrations, mimic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koppensteiner, Peter, Trinchese, Fabrizio, Fà, Mauro, Puzzo, Daniela, Gulisano, Walter, Yan, Shijun, Poussin, Arthur, Liu, Shumin, Orozco, Ian, Dale, Elena, Teich, Andrew F., Palmeri, Agostino, Ninan, Ipe, Boehm, Stefan, Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007504/
https://ncbi.nlm.nih.gov/pubmed/27581852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32553
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