Amyloid-β Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity

Amyloid-β (Aβ), a peptide thought to play a crucial role in Alzheimer's disease (AD), has many targets that, in turn, activate different second-messenger cascades. Interestingly, Aβ has been found to markedly impair hippocampal long-term potentiation (LTP). To identify a new pathway that might...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Puzzo, Daniela, Vitolo, Ottavio, Trinchese, Fabrizio, Jacob, Joel P., Palmeri, Agostino, Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725343/
https://ncbi.nlm.nih.gov/pubmed/16033898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5291-04.2005
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