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Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

According to the prevailing “amyloid cascade hypothesis,” genetic dementias such as Alzheimer’s disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive alterations. To efficiently reproduce amyloid lesions, murine...

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Bibliografiske detaljer
Main Authors: Tamayev, Robert, Matsuda, Shuji, Fà, Mauro, Arancio, Ottavio, D’Adamio, Luciano
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996452/
https://ncbi.nlm.nih.gov/pubmed/21098268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011689107
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