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Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
According to the prevailing “amyloid cascade hypothesis,” genetic dementias such as Alzheimer’s disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive alterations. To efficiently reproduce amyloid lesions, murine...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996452/ https://ncbi.nlm.nih.gov/pubmed/21098268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011689107 |
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