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APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD). Analysis of FDD(KI) mice, a mouse model of FDD genetically congruous to the human disease since they carry one mutant and one wild-type Bri2/Itm2b allele, has shown that the Danish mutation causes loss of Br...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3116289/ https://ncbi.nlm.nih.gov/pubmed/21587206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.161 |
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