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β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid-β precursor protein (APP) processing since BRI2 is an inhibitor of APP proteolysis, and APP mediates the synaptic/memory deficits in FDD. AP...

詳細記述

保存先:
書誌詳細
主要な著者: Tamayev, Robert, Matsuda, Shuji, Arancio, Ottavio, D'Adamio, Luciano
フォーマット: Artigo
言語:Inglês
出版事項: WILEY-VCH Verlag 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376850/
https://ncbi.nlm.nih.gov/pubmed/22170863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100195
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