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β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish dementia (FDD). BRI2 deficiency of FDD provokes an increase in amyloid-β precursor protein (APP) processing since BRI2 is an inhibitor of APP proteolysis, and APP mediates the synaptic/memory deficits in FDD. AP...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376850/ https://ncbi.nlm.nih.gov/pubmed/22170863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100195 |
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