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Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
BACKGROUND: A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis. The FDD mutation leads to a loss of BRI2 protein and to increased APP proce...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
BioMed Central
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3407505/ https://ncbi.nlm.nih.gov/pubmed/22537414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-19 |
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