Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

Mutations in BRI2/ITM2b genes cause Familial British and Danish Dementias (FBD and FDD), which are pathogenically similar to Familial Alzheimer Disease (FAD). BRI2 inhibits processing of Amyloid precursor protein (APP), a protein involved in FAD pathogenesis. Accumulation of a carboxyl-terminal APP...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Biundo, Fabrizio, Ishiwari, Keita, Del Prete, Dolores, D'Adamio, Luciano
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper: Gerotarget (Focus on Aging)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914259/
https://ncbi.nlm.nih.gov/pubmed/26942869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7389
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