Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-β Load in an Alzheimer's Disease Mouse Model

Memory loss, synaptic dysfunction, and accumulation of amyloid β-peptides (Aβ) are major hallmarks of Alzheimer's disease (AD). Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits...

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Publicado no:J Neurosci
Main Authors: Puzzo, Daniela, Staniszewski, Agnieszka, Deng, Shi Xian, Privitera, Lucia, Leznik, Elena, Liu, Shumin, Zhang, Hong, Feng, Yan, Palmeri, Agostino, Landry, Donald W., Arancio, Ottavio
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6666028/
https://ncbi.nlm.nih.gov/pubmed/19553447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0864-09.2009
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