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Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-β Load in an Alzheimer's Disease Mouse Model
Memory loss, synaptic dysfunction, and accumulation of amyloid β-peptides (Aβ) are major hallmarks of Alzheimer's disease (AD). Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits...
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| Pubblicato in: | J Neurosci |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6666028/ https://ncbi.nlm.nih.gov/pubmed/19553447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0864-09.2009 |
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