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Rodent models for Alzheimer’s disease drug discovery

INTRODUCTION: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia. Histophatological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein...

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Détails bibliographiques
Publié dans:Expert Opin Drug Discov
Auteurs principaux: Puzzo, Daniela, Gulisano, Walter, Palmeri, Agostino, Arancio, Ottavio
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592281/
https://ncbi.nlm.nih.gov/pubmed/25927677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17460441.2015.1041913
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