Anti-cancer agents counteracting tumor glycolysis

Por Granchi, Carlotta, Minutolo, Filippo
Publicado em 2012

Small-molecule inhibitors of human LDH5

Por Granchi, Carlotta, Paterni, Ilaria, Rani, Reshma, Minutolo, Filippo
Publicado em 2013

Estrogen Receptors Alpha (ERα) and Beta (ERβ): Subtype-Selective Ligands and Clinical Potential

Por Paterni, Ilaria, Granchi, Carlotta, Katzenellenbogen, John A., Minutolo, Filippo
Publicado em 2014

Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours

Por Granchi, Carlotta, Funaioli, Tiziana, Erler, Janine T., Giaccia, Amato J., Macchia, Marco, Minutolo, Filippo
Publicado em 2009

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Por Daniele, Simona, Giacomelli, Chiara, Zappelli, Elisa, Granchi, Carlotta, Trincavelli, Maria Letizia, Minutolo, Filippo, Martini, Claudia
Publicado no Sci Rep (2015)

Phenylpropanoids and Flavonoids from Phlomis kurdica as Inhibitors of Human Lactate Dehydrogenase

Por Bader, Ammar, Tuccinardi, Tiziano, Granchi, Carlotta, Martinelli, Adriano, Macchia, Marco, Minutolo, Filippo, De Tommasi, Nunziatina, Braca, Alessandra
Publicado no Phytochemistry (2015)

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

Por Granchi, Carlotta, Calvaresi, Emilia C., Tuccinardi, Tiziano, Paterni, Ilaria, Macchia, Marco, Martinelli, Adriano, Hergenrother, Paul J., Minutolo, Filippo
Publicado em 2013

Cyclic-ketoximes as ER beta-selective agonists

Por Granchi, Carlotta, Lapillo, Margherita, Spena, Concetta Russo, Rizzolio, Flavio, Tuccinardi, Tiziano, Martin, Teresa A., Carlson, Kathryn E., Katzenellenbogen, John A., Minutolo, Filippo
Publicado no ChemMedChem (2016)

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes

Por Bertini, Simone, De Cupertinis, Andrea, Granchi, Carlotta, Bargagli, Barbara, Tuccinardi, Tiziano, Martinelli, Adriano, Macchia, Marco, Gunther, Jillian R., Carlson, Kathryn E., Katzenellenbogen, John A., Minutolo, Filippo
Publicado em 2011

Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

Por Calvaresi, Emilia C., Granchi, Carlotta, Tuccinardi, Tiziano, Di Bussolo, Valeria, Huigens, Robert W., Lee, Hyang Yeon, Palchaudhuri, Rahul, Macchia, Marco, Martinelli, Adriano, Minutolo, Filippo, Hergenrother, Paul J.
Publicado em 2013

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents

Por Di Bussolo, Valeria, Calvaresi, Emilia C., Granchi, Carlotta, Del Bino, Linda, Frau, Ileana, Lang, Maria Chiara Dasso, Tuccinardi, Tiziano, Macchia, Marco, Martinelli, Adriano, Hergenrother, Paul J., Minutolo, Filippo
Publicado no RSC Adv (2015)

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model

Por Paterni, Ilaria, Bertini, Simone, Granchi, Carlotta, Tuccinardi, Tiziano, Macchia, Marco, Martinelli, Adriano, Caligiuri, Isabella, Toffoli, Giuseppe, Rizzolio, Flavio, Carlson, Kathryn E., Katzenellenbogen, Benita S., Katzenellenbogen, John A., Minutolo, Filippo
Publicado no J Med Chem (2015)

Salicylketoximes targeting glucose transporter 1 restrict energy supply to lung cancer cells

Por Granchi, Carlotta, Qian, Yanrong, Lee, Hyang Yeon, Paterni, Ilaria, Pasero, Carolina, Iegre, Jessica, Carlson, Kathryn E., Tuccinardi, Tiziano, Chen, Xiaozhuo, Katzenellenbogen, John A., Hergenrother, Paul J., Minutolo, Filippo
Publicado no ChemMedChem (2015)

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Por Massihnia, Daniela, Avan, Amir, Funel, Niccola, Maftouh, Mina, van Krieken, Anne, Granchi, Carlotta, Raktoe, Rajiv, Boggi, Ugo, Aicher, Babette, Minutolo, Filippo, Russo, Antonio, Leon, Leticia G., Peters, Godefridus J., Giovannetti, Elisa
Publicado no J Hematol Oncol (2017)

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Por Lucchesi, Valentina, Hurst, Dow P., Shore, Derek M., Bertini, Simone, Ehrmann, Brandie M., Allarà, Marco, Lawrence, Lyle, Ligresti, Alessia, Minutolo, Filippo, Saccomanni, Giuseppe, Sharir, Haleli, Macchia, Marco, Di Marzo, Vincenzo, Abood, Mary E., Reggio, Patricia H., Manera, Clementina
Publicado no J Med Chem (2014)