Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor

Glucose transporters and the glycolysis enzyme lactate dehydrogenase A (LDH-A) are both overexpressed in cancer cells, two proliferation tactics that underlie the phenomenon known as the Warburg effect. Herein we report the development and activity of a glucose-conjugated LDH-A inhibitor designed to...

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Detalhes bibliográficos
Main Authors: Calvaresi, Emilia C., Granchi, Carlotta, Tuccinardi, Tiziano, Di Bussolo, Valeria, Huigens, Robert W., Lee, Hyang Yeon, Palchaudhuri, Rahul, Macchia, Marco, Martinelli, Adriano, Minutolo, Filippo, Hergenrother, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919968/
https://ncbi.nlm.nih.gov/pubmed/24174263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300562
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