Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characterised by an irreversible mechanism of action and thi...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Granchi, Carlotta, Caligiuri, Isabella, Bertelli, Eleonora, Poli, Giulio, Rizzolio, Flavio, Macchia, Marco, Martinelli, Adriano, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009861/
https://ncbi.nlm.nih.gov/pubmed/28936880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1375484
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