Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s diseases, has also been demonstrated. In this study, start...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Poli, Giulio, Lapillo, Margherita, Granchi, Carlotta, Caciolla, Jessica, Mouawad, Nayla, Caligiuri, Isabella, Rizzolio, Flavio, Langer, Thierry, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009924/
https://ncbi.nlm.nih.gov/pubmed/29747534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1469017
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