Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s diseases, has also been demonstrated. In this study, start...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: Poli, Giulio, Lapillo, Margherita, Granchi, Carlotta, Caciolla, Jessica, Mouawad, Nayla, Caligiuri, Isabella, Rizzolio, Flavio, Langer, Thierry, Minutolo, Filippo, Tuccinardi, Tiziano
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Short Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009924/
https://ncbi.nlm.nih.gov/pubmed/29747534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1469017
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