Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer’s and Parkinson’s diseases, has also been demonstrated. In this study, start...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: Poli, Giulio, Lapillo, Margherita, Granchi, Carlotta, Caciolla, Jessica, Mouawad, Nayla, Caligiuri, Isabella, Rizzolio, Flavio, Langer, Thierry, Minutolo, Filippo, Tuccinardi, Tiziano
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009924/
https://ncbi.nlm.nih.gov/pubmed/29747534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1469017
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